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The cat is a dilettante in fur. -Unknown |
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Prescription items are NON-RETURNABLE and NON REFUNDABLE Mexiletine Capsule Mexiletine is a class 1B, sodium channel blocker, anti-arrhythmia drug, used to treat chronic ventricular arrhythmias in the dogs. Mexiletine is used to treat ventricular arrhythmias including PVC's and ventricular tachycardia. Mexiletine is well absorbed orally. It is primarily excreted in the urine although approximately 10% is metabolized by the liver and excreted in the feces. The half-life of this drug may be prolonged in animals with reduced cardiac output, or after an acute myocardial infarction. The half-life may also be prolonged in animals with hepatic dysfunction or severe kidney disease. The most commonly used oral drugs for the chronic treatment of ventricular arrhythmias are atenolol, sotalol, procainamide, amiodarone, and mexiletine. Mexiletine may be combined with either atenolol or sotalol in instances when monotherapy is not adequate. Mexiletine may be used to treat inherited cardiomyopathy in Boxers and dilated cardiomyopathy in Doberman pinschers. A positive response to therapy would be an 85% reduction of ventricular premature contractions. The complete elimination of ventricular arrhythmia is not considered a realistic goal. For Use In: Dogs Side Effects The most common side effects are related to the GI tract including nausea and vomiting. Giving food with mexiletine has been shown to decrease the incidence of GI side effects. Other possible side effects include central nervous system signs such as dizziness, loss of balance and trembling, shortness of breath, and cardiac signs including PVCs or chest pain. Rare side effects reported in humans include seizures, and bone marrow suppression. Precautions Mexiletine should be used with extreme caution in animals with the foll 012KV-30025 300938740017