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The cat is a dilettante in fur. -Unknown |
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Prescription items are NON-RETURNABLE and NON REFUNDABLE Primor Indications For Use Primor is for the treatment of skin and soft tissue infections (wounds and abscesses) in dogs caused by strains of Staphylococcus aureus and Escherichia coli and urinary tract infections caused by Escherichia coli, Staphylococcus spp., and Proteus mirabilis susceptible to sulfadimethoxine/ormetoprim. Description Primor is an antimicrobial drug containing sulfadimethoxine and ormetoprim in a 5 to 1 ratio. The combination of these 2 compounds results in the potentiation of sulfadimethoxine, providing increased efficacy, a broadened spectrum of activity to include some sulfonamide-resistant organisms, and reduction in the rate of resistance development. Sulfadimethoxine is a white, almost tasteless and odorless powder. Chemically, it is N1-(2,6-dimethoxy-4pyrimidinyl)-sulfanila-mide. The structural formula is: Ormetoprim is a white, almost tasteless powder. Chemically, it is 2,4-diamino-5-(4,5- dimethoxy-2methylbenzyl)-pyrimidine. The structural formula is: Toxicity And Safety 1 Toxicity data for Primor indicates that the drug is safe when used at the recommended dosage. Following oral administration of Primor to dogs at 27.5 mg/kg/day (12.5 mg/lb/day) for 8 weeks, no changes were noted in hematology, blood chemistry, urinalysis, gross pathology, and histopathology, except for elevated serum cholesterol, increased thyroid and liver weights, enlarged basophilic cells in the pituitary, and mild follicular thyroid hyperplasia. These changes are known to be associated with prolonged administration of sulfonamides to dogs and have been shown to be reversible. Adverse Reactions Conditions reported following use of sulfonamides or potentiated sulfonamides include polyarthritis, urticaria, facial 012PFZ-240MG-TAB RX101026